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Invited Commentary

FB Underwood, PT, PhD, ECS, is Professor of Physical Therapy, University of Evansville, 1800 Lincoln Ave, Evansville, IN 47722-0002

Address all correspondence to Dr Underwood at: fu2@evansville.edu

Because this article has no abstract, we have provided an extract of the full text and any section headings.

Iontophoresis of corticosteroids in the management of local inflammatory conditions is a controversial topic. The available evidence regarding the clinical efficacy of iontophoresis is contradictory and generally of low quality, with few notable exceptions. The research by Sylvestre and colleagues¹ provides much-needed clarity to the technical aspects of this treatment and should serve as a stimulus to and basis for high-quality clinical trials.

In 1992, Petelenz et al² determined in laboratory studies that dexamethasone is most effectively delivered via electromigration from the cathode of a direct current circuit. Despite their findings, many reference textbooks for electrotherapy used in professional (entry-level) physical therapist education programs persisted in listing dexamethasone as a positively charged ion. It is encouraging that most current textbooks (eg, Cameron,³ Prentice,⁴ Michlovitz and Nolan,⁵ Hayes and Nelson⁶) now clearly state that dexamethasone has a negative charge in solution and, therefore, should be . . . [Full Text of this Article]

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