HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: ptj.20080008v1 88/11/1322    most recent Submit a response Alert me when this article is cited Alert me when Rapid Responses are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cade, W T. Search for Related Content PubMed PubMed Citation Articles by Cade, W T. Related Collections Other Diseases or Conditions Cardiovascular/Pulmonary System: Other Diabetes Social Bookmarking                      What's this?

Diabetes-Related Microvascular and Macrovascular Diseases in the Physical Therapy Setting

WT Cade, PT, PhD, is Assistant Professor of Physical Therapy and Medicine, Washington University School of Medicine, Campus Box 8502, 4444 Forest Park Blvd, St Louis, MO 63108 (USA)

Address all correspondence to Dr Cade at: cadet{at}wusm.wustl.edu

Physical therapists commonly treat people with diabetes for a wide variety of diabetes-associated impairments, including those from diabetes-related vascular disease. Diabetes is associated with both microvascular and macrovascular diseases affecting several organs, including muscle, skin, heart, brain, and kidneys. A common etiology links the different types of diabetes-associated vascular disease. Common risk factors for vascular disease in people with diabetes, specifically type 2 diabetes, include hyperglycemia, insulin resistance, dyslipidemia, hypertension, tobacco use, and obesity. Mechanisms for vascular disease in diabetes include the pathologic effects of advanced glycation end product accumulation, impaired vasodilatory response attributable to nitric oxide inhibition, smooth muscle cell dysfunction, overproduction of endothelial growth factors, chronic inflammation, hemodynamic dysregulation, impaired fibrinolytic ability, and enhanced platelet aggregation. It is becoming increasingly important for physical therapists to be aware of diabetes-related vascular complications as more patients present with insulin resistance and diabetes. The opportunities for effective physical therapy interventions (such as exercise) are significant.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				A. M. Castro-Sanchez, C. Moreno-Lorenzo, G. A. Mataran-Penarrocha, B. Feriche-Fernandez-Castanys, G. Granados-Gamez, and J. M. Quesada-Rubio Connective Tissue Reflex Massage for Type 2 Diabetic Patients with Peripheral Arterial Disease: Randomized Controlled Trial Evid. Based Complement. Altern. Med., November 23, 2009; (2009) nep171v1. [Abstract] [Full Text] [PDF]

				M. J Mueller, D. Zou, K. L Bohnert, L. J Tuttle, and D. R Sinacore Plantar Stresses on the Neuropathic Foot During Barefoot Walking Physical Therapy, November 1, 2008; 88(11): 1375 - 1384. [Abstract] [Full Text] [PDF]

				J. S Brach, J. B Talkowski, E. S Strotmeyer, and A. B Newman Diabetes Mellitus and Gait Dysfunction: Possible Explanatory Factors Physical Therapy, November 1, 2008; 88(11): 1365 - 1374. [Abstract] [Full Text] [PDF]

				A. D Deshpande, M. Harris-Hayes, and M. Schootman Epidemiology of Diabetes and Diabetes-Related Complications Physical Therapy, November 1, 2008; 88(11): 1254 - 1264. [Abstract] [Full Text] [PDF]

				L. Stehno-Bittel Intricacies of Fat Physical Therapy, November 1, 2008; 88(11): 1265 - 1278. [Abstract] [Full Text] [PDF]

				T. N Hilton, L. J Tuttle, K. L Bohnert, M. J Mueller, and D. R Sinacore Excessive Adipose Tissue Infiltration in Skeletal Muscle in Individuals With Obesity, Diabetes Mellitus, and Peripheral Neuropathy: Association With Performance and Function Physical Therapy, November 1, 2008; 88(11): 1336 - 1344. [Abstract] [Full Text] [PDF]

				E. A. Gulve Exercise and Glycemic Control in Diabetes: Benefits, Challenges, and Adjustments to Pharmacotherapy Physical Therapy, November 1, 2008; 88(11): 1297 - 1321. [Abstract] [Full Text] [PDF]

				C. S Kirkness, R. L Marcus, P. C LaStayo, C. V Asche, and J. M Fritz Diabetes and Associated Risk Factors in Patients Referred for Physical Therapy in a National Primary Care Electronic Medical Record Database Physical Therapy, November 1, 2008; 88(11): 1408 - 1416. [Abstract] [Full Text] [PDF]

				M. J Mueller People With Diabetes: A Population Desperate for Movement Physical Therapy, November 1, 2008; 88(11): 1250 - 1253. [Full Text] [PDF]