HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when Rapid Responses are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Basso, D M. Search for Related Content PubMed PubMed Citation Articles by Basso, D M. Related Collections Gait and Locomotion Training Anatomy: Central Nervous System and Neuromuscular System Spinal Cord Injuries Social Bookmarking                      What's this?

Neuroanatomical Substrates of Functional Recovery After Experimental Spinal Cord Injury: Implications of Basic Science Research for Human Spinal Cord Injury

DM Basso, PT, EdD, Assistant Professor, Division of Physical Therapy, School of Allied Medical Professions, The Ohio State University, 306 SAMP, 1583 Perry St, Columbus, OH 43210 (USA) (basso.2{at}osu.edu)

Human spinal cord injury (SCI) is a devastating condition that results in persistent motor deficits. Considerable basic and clinical research is directed at attenuating these deficits. Many basic scientists use animal models of SCI to: (1) characterize lesion development, (2) determine the role of spared axons in recovery, and (3) develop therapeutic interventions based on these findings. In this article, current research is reviewed that indicates: (1) most individuals with SCI will have some sparing of white matter at the lesion epicenter even when the lesion appears clinically complete, (2) even minimal tissue sparing has a profound impact on segmental systems and recovery of function, and (3) facilitatory intervention such as weight bearing and locomotor training after SCI may be more effective than compensatory strategies at inducing neuroplasticity and motor recovery. Body weight supported treadmill step training is discussed as an example of new facilitatory interventions based on basic science research using animal models.

Key Words: Experimental models • Flexor withdrawal reflex • Locomotion • Neuroplasticity • Treadmill training

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				I. C Maier and M. E Schwab Sprouting, regeneration and circuit formation in the injured spinal cord: factors and activity Phil Trans R Soc B, September 29, 2006; 361(1473): 1611 - 1634. [Abstract] [Full Text] [PDF]

				K. J. Hutchinson, F. Gomez-Pinilla, M. J. Crowe, Z. Ying, and D. M. Basso Three exercise paradigms differentially improve sensory recovery after spinal cord contusion in rats Brain, June 1, 2004; 127(6): 1403 - 1414. [Abstract] [Full Text] [PDF]

				V. Dietz and S. J. Harkema Locomotor activity in spinal cord-injured persons J Appl Physiol, May 1, 2004; 96(5): 1954 - 1960. [Abstract] [Full Text] [PDF]

				V. L. Arvanian, P. J. Horner, F. H. Gage, and L. M. Mendell Chronic Neurotrophin-3 Strengthens Synaptic Connections to Motoneurons in the Neonatal Rat J. Neurosci., September 24, 2003; 23(25): 8706 - 8712. [Abstract] [Full Text] [PDF]

				R. D de Leon, R. R Roy, and V R. Edgerton Is the Recovery of Stepping Following Spinal Cord Injury Mediated by Modifying Existing Neural Pathways or by Generating New Pathways? A Perspective Physical Therapy, December 1, 2001; 81(12): 1904 - 1911. [Abstract] [Full Text] [PDF]