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The Effects of Intense Physical Exercise on Secondary Antibody Response in Young and Old Mice

ZF Kapasi, PT, PhD, is Assistant Professor, Division of Physical Therapy, Department of Rehabilitation Medicine, Emory University School of Medicine, 1441 Clifton Rd NE, Atlanta, GA 30322 (USA) (zkapasi{at}emory.edu). Address all correspondence to Dr Kapasi
PA Catlin, PT, EdD, is Professor and Director, Division of Physical Therapy, Department of Rehabilitation Medicine, Emory University School of Medicine
DR Joyner, PT, is Physical Therapist, Tooele Valley Healthcare System, Tooele, Utah
ML Lewis, PT, is Staff II Physical Therapist, Washington Hospital Center, Washington, DC
AL Schwartz, PT, is Physical Therapist, Center for Rehabilitation Medicine, Emory University Hospital
EL Townsend, PT, is Research Specialist, NICHD Study of Early Child Care and Youth Development, University of Virginia, Charlottesville, Va

Background and Purpose. Based largely on data from young subjects, intense physical exercise is believed to suppress immune function. In addition, immune function, including secondary antibody response, declines with advancing age. Therefore, intense exercise in old subjects may further suppress the secondary antibody response. The purpose of this in vivo study was to investigate the effects of intense physical exercise on secondary antibody response in young (6–8 weeks) and old (22–24 months) C57BL/6 mice. Subjects and Methods. Data were obtained from 22 young and 18 old C57BL/6 mice that were immunized to human serum albumin (HSA) and randomly divided into 3 groups. Two groups were exposed to a single bout of intense exercise to exhaustion and immediately boosted with an injection of HSA. The first group did not exercise further, but the second group continued with daily bouts of intense exercise to exhaustion for 9 days. The third group (control group) did not undergo intense exercise, but received the booster injection of HSA at the same time as the other groups. Ten days after the HSA booster injection, when high level of antibodies are produced in secondary antibody response, serum anti-HSA antibodies were measured by enzyme-linked immunosorbent assay. Results. Young mice did not show suppression of secondary antibody response following intense exercise. However, old mice, exposed to a single bout of intense exercise, had an enhanced response similar to the response seen in young control mice. Conclusion and Discussion. The widely accepted hypothesis of immunosuppression resulting from intense exercise may not be true for old mice.

Key Words: Intense exercise training • Old mice • Secondary antibody response

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				Z. F. Kapasi, M. L. McRae, and R. Ahmed Suppression of viral specific primary T-cell response following intense physical exercise in young but not old mice J Appl Physiol, February 1, 2005; 98(2): 663 - 671. [Abstract] [Full Text] [PDF]

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