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Effect of High-Voltage Pulsed Current and Alternating Current on Macromolecular Leakage in Hamster Cheek Pouch Microcirculation

K Taylor, PhD, PT, is Associate Professor and Chairman, Department of Physical Therapy, Daemen College, 4380 Main St, Box 784, Amherst, NY 14226 (USA) (ktaylor@daemen.edu). This study was completed in partial fulfillment of the requirements for Dr Taylor's Doctor of Philosophy degree in anatomy and cell biology at the State University of New York at Buffalo.
FC Mendel, PhD, is Associate Professor, Department of Anatomy and Cell Biology, State University of New York at Buffalo.
DR Fish, PhD, PT, is Associate Professor, Department of Physical Therapy and Exercise Science, and Associate Dean for Academic Affairs, School of Health-Related Professions, State University of New York at Buffalo.
R Hard, PhD, is Associate Professor, Department of Anatomy and Cell Biology, State University of New York at Buffalo.
HW Burton, PhD, is Associate Professor and Chairman, Exercise Science Program, State University of New York at Buffalo.

Background and Purpose. Electrical stimulation (ES) is supposed to affect edema formation by inhibiting macromolecular leakage from microvessels. The purpose of the study was to determine the effects of various forms of ES on macromolecular leakage from microvessels. Subjects. Fifty-three hamsters were randomly assigned to one of seven groups: a control group (histamine only); groups that received histamine with cathodal high-voltage pulsed current (HVPC) at intensities of 90%, 50%, and 10% of visible motor threshold (VMT); groups that received anodal HVPC at intensities of 90% and 50% of VMT; and a group that received alternating current (AC) at 90% of VMT. Methods. Anesthetized animals were injected with fluorescein-labeled dextran. Macromolecular leakage was determined by computer analysis of fluorescence microscopy images for 5 minutes after treatment. Results. When compared with controls, leakage was less in groups treated with cathodal HVPC at 90% and 50% of VMT and anodal HVPC at 90% of VMT. Conclusion and Discussion. Cathodal and anodal HVPC, but not AC, curb macromolecular leakage from the microvessels of histamine-treated hamsters.

Key Words: Edema • Electrical stimulation • High-voltage pulsed current • Inflammation • Microvessel permeability

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