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Invited Commentary

PR Cavanaugh, PhD, is Distinguished Professor of Locomotion Studies, Biobehavioral Health, Medicine, and Orthopaedic Surgery, Centre for Locomotion Studies, The Pennsylvania State University, University Park, PA 16802

This excerpt was created in the absence of an abstract.

The search to understand the neural control of human locomotion has been advanced by a number of pathological models and, as Mueller and co-workers point out in this article, the patient with diabetes and neuropathy has a number of features that may allow this understanding to progress to deeper levels. This is a view that our group shares enthusiastically.^1,2

Peripheral neuropathy, which may occur in 25% to 50% of patients who have had the disease for more than 10 years, affects all divisions of the peripheral nervous system (sensory, motor, and autonomic).³ The prevailing view of the control of locomotion is that central pattern generators provide the fundamental control input, which is modulated by peripheral feedback to accomplish the desired result.^4,5...

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